What is a Fistulas?
Fistulas are pretty common is people who have Chrons disease, so what are they? Well basically they are abnormal connections or passageways between organs or vessels that should not normally connect to each other.
What Are Perianal Fistulas?
A perianal fistula is an abnormal connections (fistula) between the anus and rectum with another organ or vessel such as the skin or the vagina. This can be a very debilitating condition, and can lead to a big drop in the quality of life for anyone who has Perianal fistuals and Chrons disease as they can cause anal incontinence and / or infections.
According to research about 12 percent of people with chrons disease have Perianal fistulas, this is a huge amount as there are said to be at least half a million people with Crohn's disease in the US alone.
How are Fistulas treated?
Current treatments rely mainly upon surgery, which unfortunatly has a pretty poor success rate and is obviously very invasive. Anti TNF-alpha, is also used which only has a sucess rate (complete absence of fistulae) of only 36%.
So there is a huge need for another more effective and less invasive treatment for people who have chrons disease and fistulas.
Help with Fistulas on the way?
Possibly! A product with the catchy tilte of Cx401, is in development and is to be used for the treatment of perianal fistulas common in people with Chrons disease.
What is Cx401?
Cx401 uses stem-cells not derived from embryo's to treat perianal fistulas in Chrons and also non Chrons Disease patients. There has already been a Phase 2 clinical trial which has shown the effectiveness and the safety of Cx401. The Patent application has been submitted, and fingers crossed for all people with Chrons Disease who have perianal fistulas, if it is granted it could provide protection until the year 2025!
Thursday 4 October 2007
Perianal Fistulas in Chrons Disease
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4 comments:
WOULDN'T THAT BE WONDERFUL. HOW MANY PHASES DO THEY HAVE TO GO THROUGH BEFORE IS APPROVED. WONDER HOW EXPENSIVE IT WILL BE. LIKE REMICADE. IS IT IV THERAPY TOO. REMICADE ISN'T HELPING ME. I'LL ADD THIS TO MY PRAYERS. THANK YOU KEEP ME POSTED
I am very hopeful that there will be such a cure and there aren't any terrible side effects. I was diagnosed with first IBS, then ulcerative colitis and then about ten years ago chrons. Now I believe that I do have a fistula.
I pray for a great new treatment.
I have Perianal Chrons and I now have 4 Perianal Fistulas,in a semicircal around the Anas. They are quite painful and one of them has burst and is oozing dascharge.
I am on Imuran Tablets, Asacolon,Mortilium and Fybogel.
I dont feel that Medication is doing much, but then, I dont know how I would be without my medication.
Any help with Perianal Chrons & 4 Perianal Fistula's.I am on, Imuran Tablets, Asacolon, Mortilium and Fybogel. Idont get any remission and the Fistulas are quite painful.
One Fistula has burst and is oozing discharhe.
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